Although there is consensus on the fact that ionizing radiation used in radiological examinations can affect health, the stochastic nature of risk makes it difficult to anticipate and assess specific health implications for patients. The issue of radiation protection is peculiar as any dosage received in life is cumulative, the sensitivity to radiation is highly variable from one person to another, and between 20 % and 50 % of radiological examinations appear not to be necessary. In this context, one might (...) reasonably assume that information and patient consent would play an important role in regulating radiological practice. However, there is to date no clear consensus regarding the nature and content of—or even need for—consent by patients exposed to ionizing radiation. While law and ethics support the same principles for respecting the dignity of the person, in the context of radiology practice, they do not provide a consistent message to guide clinical decision-making. This article analyzes the issue of healthcare professionals’ duty to inform and obtain patient consent for radiological examinations. Considering that both law and ethics have as one of their aims to protect vulnerable populations, it is important that they begin to give greater attention to issues raised by the use of ionizing radiation in medicine. While the situation in Canada serves as a backdrop for a reflective analysis of the problem, the conclusions are pertinent for professional practice in other jurisdictions because the principles underlying health law and jurisprudence are fairly general. (shrink)

It has become a truism that the ethics of artificial intelligence (AI) is necessary and must help guide technological developments. Numerous ethical guidelines have emerged from academia, industry, government and civil society in recent years. While they provide a basis for discussion on appropriate regulation of AI, it is not always clear how these ethical guidelines were developed, and by whom. Using content analysis, we surveyed a sample of the major documents (_n_ = 47) and analyzed the accessible information regarding (...) their methodology and stakeholder engagement. Surprisingly, only 38% report some form of stakeholder engagement (with 9% involving citizens) and most do not report their methodology for developing normative insights (15%). Our results show that documents with stakeholder engagement develop more comprehensive ethical guidance with greater applicability, and that the private sector is least likely to engage stakeholders. We argue that the current trend for enunciating AI ethical guidance not only poses widely discussed challenges of applicability in practice, but also of transparent development (as it rather behaves as a black box) and of active engagement of diversified, independent and trustworthy stakeholders. While most of these documents consider people and the common good as central to their telos, engagement with the general public is significantly lacking. As AI ethics moves from the initial race for enunciating general principles to more sustainable, inclusive and practical guidance, stakeholder engagement and citizen involvement will need to be embedded into the framing of ethical and societal expectations towards this technology. (shrink)

Cho and Martinez-Martin (2023) provide a compelling critique of the profound influence that data sourcing for artificial intelligence (AI) has on the healthcare sector. They emphasize the need for...

Increasing attention and efforts are being put towards engaging patients in health research, and some have even argued that patient engagement in research is an ethical imperative. Yet there is relatively little empirical data on ethical issues associated with PER. A three-round Delphi survey was conducted with a panel of early-career researchers involved in PER. One of the objectives was to examine the ethical dimensions of PER as well as ECRs’ self-perceived level of preparedness to conduct PER ethically. The study (...) was conducted among awardees of the Québec SPOR-SUPPORT Unit in Canada, who represent the next generation of researchers involved in PER. Many themes were addressed throughout the study, such as definition, values, patients’ roles, expected characteristics of patients, and anticipated challenges. Open-ended questions were used, and all quantitative data were collected through statements using 7-point Likert scales. Between April and November 2016, 25 ECRs were invited to participate; 18 completed both the first and second rounds, and 16 completed the third round. Panelists consisted of nine women and seven men with various backgrounds. The majority were between 25 and 44 years old. Panelists’ responses showed PER raises important ethical issues: 1) professionalization of patients involved in research ; 2) adequate remuneration of patients; 3) fair recognition of patients’ experiential knowledge; and 4) tokenism. While the panelists felt moderately prepared to confront these ethical issues, they reported being uncomfortable applying for an ethics certificate for a PER project. If PER is an ethical imperative, it is vital to establish clear ethical standards and to train and support the PER community to identify and resolve ethical issues. Despite their overall readiness to conduct PER, panelists did not feel adequately prepared to address many of these issues. It is not easy for ECRs to reconcile ethical desiderata and logistical imperatives. Additional research should focus on supporting the responsible conduct of PER, which, if not done, can undermine the credibility and feasibility of the entire PER enterprise. (shrink)

Bioethics, like the sixteenth-century commedia dell’arte, is a master of revelation. At the heart of this is a propensity to highlight that what we see is as much truthful and elegant as it is made up of pretence and staging. Must we persuade ourselves that what is false is not false, that what is true is changeable and fragile? Is it possible to serve two masters? Is it possible to get by without antics and disgrace? The Odelet is at once (...) a cryptic portent of the past, present and future of bioethics and a reflection on the capacity of the field to act as a motor for social change. (shrink)

Promotion of prescription drugs may appear to be severely limited in some jurisdictions due to restrictions on direct-to-consumer advertising. However, in most jurisdictions, strategies exist to raise consumer awareness about prescription drugs, notably through the deployment of direct-to-consumer information campaigns that encourage patients to seek help for particular medical conditions. In Canada, DTCI is presented by industry and regulated by Health Canada as being purely informational activities, but their design and integration in broader promotional campaigns raise very similar ethical concerns (...) as those associated with DTCA. Specifically, DTCI can be an effective means of familiarizing the public with the scope and benefits of a particular prescription drug and so, like DTCA, can promote increased patient-consumer demand and thus a problematic rise in the prescribing and use of medications that may be neither the most appropriate nor the most cost-effective. Yet, with DTCI the industry is playing within the existing rules and regulations set by health regulators. To respond appropriately to this regulatory incoherence, we argue that DTCI should be regulated as a type of direct-to-consumer indirect advertising. Even if the case and specific regulations presented here are Canadian, the implications extend to every country that has a partial or total prohibition on DTCA. (shrink)

Research Ethics, Volume 18, Issue 2, Page 126-131, April 2022. Engaging citizens and patients in research has become a truism in many fields of health research. It is now seen as a laudable—if not compulsory—activity in research for yielding more impactful and meaningful citizen/patient outcomes and steering research in the right direction. Although this research approach is increasingly common and commendable, we recently encountered a major obstacle in obtaining an ethics certificate from an institutional review board to conduct a study (...) that places citizen/patient perspectives on equal footing with those of academic/policy experts. The obstacle was the interpretation of fairness in terms of compensation for research participation. In terms of research ethics, this raised an important question: Should all types of participants be compensated equally, or should exceptions be made for citizen/patient participants? We argue that there are good reasons for exceptionalism and that clearer guidance on citizen/patient engagement in research should be embedded into research ethics doctrine. (shrink)

Engaging citizens and patients in research has become a truism in many fields of health research. It is now seen as a laudable—if not compulsory—activity in research for yielding more impactful and meaningful citizen/patient outcomes and steering research in the right direction. Although this research approach is increasingly common and commendable, we recently encountered a major obstacle in obtaining an ethics certificate from an institutional review board to conduct a study that places citizen/patient perspectives on equal footing with those of (...) academic/policy experts. The obstacle was the interpretation of fairness in terms of compensation for research participation. In terms of research ethics, this raised an important question: Should all types of participants be compensated equally, or should exceptions be made for citizen/patient participants? We argue that there are good reasons for exceptionalism and that clearer guidance on citizen/patient engagement in research should be embedded into research ethics doctrine. (shrink)

Engaging patients in research conduct and agenda setting is increasingly considered as an ethical imperative, and a way to transcend views of patients as passive subjects by fostering their empowerment. However, patient engagement in research is still an emerging approach with debated definitional and operational frameworks. This song addresses the sometimes difficult encounter and elusive mutual understanding between researchers and patients. “What is PER?” is an impressionistic illustration of the challenges and issues that can be found in the universe of (...) patient engagement in research. (shrink)

Engaging patients in research conduct and agenda setting is increasingly considered as an ethical imperative, and a way to transcend views of patients as passive subjects by fostering their empowerment. However, patient engagement in research is still an emerging approach with debated definitional and operational frameworks. This song addresses the sometimes difficult encounter and elusive mutual understanding between researchers and patients. “What is PER?” is an impressionistic illustration of the challenges and issues that can be found in the universe of (...) patient engagement in research. (shrink)

Cohen’s (2023) mapping exercise of possible bioethical issues emerging from the use of ChatGPT in medicine provides an informative, useful, and thought-provoking trigger for discussions of AI ethic...

Bioethics experts played a key role in ensuring a coherent ethical response to the COVID-19 pandemic in the fields of healthcare, public health, and scientific research in Canada. In the province of Quebec, a group of academic and practicing bioethicists met periodically in the early months of the pandemic to discuss approaches and solutions to ethical dilemmas encountered during the crisis. These meetings created the opportunity for a national survey of bioethics practitioners from different fields. The survey, in which forty-five (...) Canadian bioethics practitioners (clinical ethicists, ethicist members of REBs and government health policy ethicists, or any bioethicist practicing outside of academia) participated, explored their concerns, challenges and opportunities during the first wave of the pandemic, with the objective of informing bioethics research about the difficulties experienced by bioethicists “in the field”. Participants reported increased stress levels, increased workloads, and a greater proportion of their work being devoted to public health ethics. Most of their concerns focused on groups other than themselves, such as health professionals, patients, research participants, and people in vulnerable socio-economic situations. An optimism about the future of bioethics was noted due to an increased awareness of the importance of bioethics by the public and by health and research institutions. (shrink)

L’érosion actuelle de la confiance du public envers les campagnes de vaccination et les décisions de politiques publiques qui y sont associées, aggravée par des scandales comme ceux relatifs à la pandémie H1N1 et l’utilisation du Tamiflu™, risque de diminuer de façon significative l’efficacité de ces interventions importantes pour la santé publique. Un manque de confiance de la population envers les acteurs de santé publique peut conduire à une méfiance accrue face aux interventions, pouvant ainsi compromettre l’atteinte des objectifs recherchés (...) par une intervention spécifique et, conséquemment, avoir un impact important sur les bénéfices attendus pour la population visée par cette intervention. Dans la production des avis d’experts, les membres des comités consultatifs d’experts en immunisation (CCEI) peuvent avoir une influence importante sur la prise de décision publique, notamment, sur la sélection par les décideurs de santé publique de vaccins en particulier et la façon dont les campagnes de vaccination seront déployées. En contrepartie de cette influence sur les décisions publiques, une indépendance et une transparence sont attendues de leur part puisque des mécanismes de divulgation et de gestion de conflits d’intérêts (CI) imparfaits peuvent affecter négativement la confiance du public à l’égard de telles décisions. Il apparaît donc important de s’assurer que des mécanismes de gestion des CI, transparents et robustes, existent pour ces comités. Dans cette étude, les avis ou rapports d’évaluation de la pertinence de la vaccination préparés par un CCEI au Québec ont été examinés pour quatre types de maladies évitables par la vaccination (infections invasives à méningocoques et à pneumocoques, coqueluche et virus du papillome humain). Le but était de : 1) identifier les CI divulgués par les membres du CCEI dans leurs rapports comparativement à ceux déclarés dans leurs publications scientifiques pour ces mêmes infections ; 2) analyser la nature des CI (réel, potentiel, apparent, personnel, financier, institutionnel, etc.) et l’impact potentiel (risque) sur la prise de décision impartiale et sur la confiance du public ; et 3) évaluer les mécanismes de gestion de CI actuellement utilisés par ce CCEI. Les résultats de cette étude montrent que très peu de rapports du CCEI contiennent une section sur les CI par rapport à la pléthore divulguée dans les publications scientifiques publiées par les membres du CCEI. De plus, les CI divulgués dans les rapports fréquemment ne correspondent pas à ceux décrits dans les publications scientifiques. Il serait donc important d’introduire des mesures visant à accroître la transparence des experts en immunisation et d’améliorer les mécanismes de divulgation et de gestion des CI afin de veiller à ce que la confiance du public envers les décideurs en santé publique soit maintenue et améliorée. (shrink)

In Québec, the Act Respecting Access to Documents Held by Public Bodies and the Protection of Personal Information provides an exception to transparency to most public institutions where public health research is conducted by allowing them to not disclose their uses of personal data. This exceptionalism is ethically problematic due to important concerns and we argue that all those who conduct research should be transparent and accountable for the work they do in the public interest.

Over the last decade there has been a noticeable increase in attention, on the part of public health scholars and professionals, to the important ethical challenges that arise in the context of public health policy, practice and research. This has arguably been a driver for the development of public health ethics as both a specialized field of study in bioethics and a subject for professional education. But how is PHE taught in public health programs and schools? Are current educational approaches (...) sufficient to provide future professionals with the necessary tools to address the diverse ethical challenges they will encounter? In this article, we examine the international public health and bioethics literatures regarding PHE education in public health programs and schools. Specifically, we 1) summarize the results from studies that describe PHE education in the United States, Europe, Canada and in some developing countries, 2) explore current attitudes and educational approaches toward ethics curricula in public health, and 3) identify and discuss reported barriers to PHE education. We conclude with some general recommendations and a research agenda to guide future work on implementing PHE into different public health programs. (shrink)

How to engage the public in a reflection on the most pressing ethical issues of our time? What if part of the solution lies in adopting an interdisciplinary and collaborative strategy to shed light on critical issues in bioethics? An example is Art + Bioéthique, an innovative project that brought together bioethicists, art historians and artists with the aim of expressing bioethics through arts in order to convey the “sensitive” aspect of many health ethics issues. The aim of this project (...) was threefold: 1) to identify and characterize mechanisms for the meeting of arts and bioethics; 2) to experiment with and co-construct a dialogue between arts and bioethics; and 3) to initiate a public discussion on bioethical issues through the blending of arts and bioethics. In connection with an exhibition held in March 2016 at the Espace Projet, a non-profit art space in Montréal, the project developed a platform that combined artworks, essays and cultural & scientific mediation activities related to the work of six duos of young bioethics researchers and emerging artists. Each duo worked on a variety of issues, such as the social inclusion of disabled people, the challenges of practical applications of nanomedicine and regenerative medicine, and a holistic approach to contemporary diseases. This project, which succeeded in stimulating an interdisciplinary dialogue and collaboration between bioethics and arts, is an example of an innovative approach to knowledge transfer that can move bioethics reflection into the public space. (shrink)

How to engage the public in a reflection on the most pressing ethical issues of our time? What if part of the solution lies in adopting an interdisciplinary and collaborative strategy to shed light on critical issues in bioethics? An example is Art + Bioéthique, an innovative project that brought together bioethicists, art historians and artists with the aim of expressing bioethics through arts in order to convey the “sensitive” aspect of many health ethics issues. The aim of this project (...) was threefold: 1) to identify and characterize mechanisms for the meeting of arts and bioethics; 2) to experiment with and co-construct a dialogue between arts and bioethics; and 3) to initiate a public discussion on bioethical issues through the blending of arts and bioethics. In connection with an exhibition held in March 2016 at the Espace Projet, a non-profit art space in Montréal, the project developed a platform that combined artworks, essays and cultural & scientific mediation activities related to the work of six duos of young bioethics researchers and emerging artists. Each duo worked on a variety of issues, such as the social inclusion of disabled people, the challenges of practical applications of nanomedicine and regenerative medicine, and a holistic approach to contemporary diseases. This project, which succeeded in stimulating an interdisciplinary dialogue and collaboration between bioethics and arts, is an example of an innovative approach to knowledge transfer that can move bioethics reflection into the public space. (shrink)

This paper opens a critical conversation about the ethics of international bioethics conferencing and proposes principles that commit to being anti-discriminatory, global, and inclusive. We launch this conversation in the Section, Case Study, with a case example involving the International Association of Bioethics’ (IAB’s) selection of Qatar to host the 2024 World Congress of Bioethics. IAB’s choice of Qatar sparked controversy. We believe it also may reveal deeper issues of Islamophobia in bioethics. The Section, Principles for International Bioethics Conferencing, sets (...) forth and defends proposed principles for international bioethics conferencing. The Section, Applying Principles to Site Selection applies the proposed principles to the case example. The Section, Applying Principles Beyond Site Selection addresses other applications of the proposed principles. The Section, Objections responds to objections. We close (in the Section, Conclusion) by calling for a wider discussion of our proposed principles.One-Sentence Capsule Summary: How should bioethicists navigate the ethics of global bioethics conferencing? (shrink)

Drug exceptional access programs (DEAPs) exist across Canada to address gaps in access to pharmaceuticals. These programs circumvent standard procedures, raising epistemic, economic, social and political issues. This commentary provides insights into these issues by revealing the context and procedures on which these programs depend.

Healthcare providers have been central actors in containing the COVID-19 pandemic. Although potentially very beneficial, the implementation of large-scale rapid serological tests raises ethical dilemmas and affects HCPs’ capacity to work in optimal conditions. In this regard, we call for attention to address specific and urgent ethical issues distinctively affecting HCPs following the availability and possible mandatory use of rapid serological tests for COVID-19.

Dans cet ouvrage, l'auteur se livre à une comparaison conceptuelle entre le principe de précaution et le principe responsabilité. Il combat la démarche tendancieuse des penseurs de la précaution qui, à l'image de Corinne Lepage, dont la conception a été reprise par le chef de l'Etat français lors du " Grenelle de l'Environnement ", assimilent précaution et responsabilité, réduisant la seconde à la première. Précaution et responsabilité ne sont en réalité absolument pas réductibles, et le principe responsabilité tel que défini (...) par Hans Jonas contient les germes d'une remise en question du mode de développement occidental, dont la notion de développement durable est actuellement le fer de lance, que le principe de précaution ne permet pas - et qu'il interdit même. Politique de Cassandre dévoile ainsi l'escroquerie politico-intellectuelle dont le principe de précaution est la manifestation, et dont le " Grenelle de l'environnement " est le dernier avatar. La responsabilité politique ne consiste à intervenir ni en aval de la catastrophe comme nous y oblige le développement techno-scientifique, ni en amont de la catastrophe et en aval des causes de cette catastrophe comme nous y incite le principe de précaution, mais en amont des causes de la catastrophe. Cet essai, à la fois philosophique, politique et poétique, tente d'allier la rigueur de la démarche intellectuelle, le souci moral de la pratique et la sensibilité humaine. (shrink)

This chapter contains section titled: Metaphysics as Ontology The Nature of the Human Being and the Origins of Occasionalism.

Quoiqu’il en soit de la distinction cartésienne entre le moi et l’âme, les classiques, de Malebranche à Fénelon, de Leibniz à Locke, tendent à identifier celui-là à celle-ci, dans un oubli radical du corps, simplement uni à elle. À cet égard, Condillac représente un véritable tournant. Si les cadres de sa métaphysique paraissent reconduire un dualisme substantiel assez strict, son sensualisme permet de thématiser un mode original de présence du corps. Le moi est désormais incorporé, voire incarné. La présente étude (...) analyse la genèse du moi tout au long du Traité des sensations, en procédant à partir de l’impasse initiale à laquelle conduit la voie lockienne reposant sur la fonction de la mémoire, jusqu’aux analyses relatives à la fonction existentielle du toucher. (shrink)

En identifiant l’ ego et la substance, Descartes affirme qu’il subsiste par lui-même et qu’il est le support des modes de la pensée, conformément aux deux caractères reconnus à la substance. Sans interroger la signification de cette équivalence, la présente étude examine la manière dont la postérité, de Locke et Malebranche jusqu’aux Lumières, récuse les principales affirmations qu’implique le dire cartésien. L’ ego se libère d’une substance devenue inutile autant qu’invisible. Les nouvelles figures du moi incarnent à leur manière la (...) mutation, si ce n’est la crise de la métaphysique. Un motif originairement cartésien (le fait que la substance ne nous affecte pas immédiatement), explique paradoxalement la récusation du cartésianisme lui-même. (shrink)

Comme nombre de ses contemporains, Buffier conçoit la métaphysique comme une théorie des principes généraux de la connaissance humaine, principes sur lesquels se fondent les sciences. Dans ce cadre, il est nécessaire de considérer les vérités générales premières et leur origine, ainsi que de mettre en évidence le critère de leur certitude. Dans cette perspective, le sens commun est compris comme la source première de notre connaissance. Buffier apparaît ainsi être le premier penseur du sens commun, qu’il élève au statut (...) de faculté cognitive pleine et entière. Le sens commun n’est plus opposé à la métaphysique abstraite mais devient son premier opérateur. (shrink)

Cette dimension d’immensité est la première qui me vient à l’esprit, dès lors qu’il est question d’aborder la nature. Nature est un mot qui avait presque disparu, de l’université en tout cas. À partir de lectures hâtives, de Foucault notamment, on en était arrivé à ne plus voir dans la nature que l’illusion voire le fantasme d’une originarité perdue. Or cela, je ne l’ai jamais pensé, je ne l’ai jamais cru, j’ai toujours pensé, au contraire, qu’avec phusis et bios, nous (...) avions un infini de la... (shrink)

La question des mondes possibles, quel que soit ce que le syntagme recouvre, est assurément une sorte de non-lieu cartésien. En conséquence, notre propos voudrait surtout contribuer, en faisant apparaître les motifs profonds qui amènent Descartes à refuser jusqu’aux termes d’une problématique qui lui est pourtant largement contemporaine, à élucider les conditions théoriques qui, à l’inverse, semblent requises pour que la notion retrouve sa consi...

La relation de Rousseau à Descartes est complexe, à la fois distante et essentielle. Rejetant la physique et une bonne part de la philosophie première cartésiennes, l’auteur de L’Émile ne renonce pas pour autant à faire du cogito un élément décisif ; il le maintient au prix d’une transposition qu’autorise le cartésianisme lui-même, qui considère aussi la sensation comme un mode de la cogitation. On suggère ici que par cette fidélité paradoxale à Descartes, Rousseau dévoile une part de son rapport (...) particulier à la métaphysique elle-même. (shrink)

This paper aims at questioning Berkeley's formula: « I am not for changing things into ideas, but rather ideas into things » (Three Dialogues). It shows that the identification of ideas with things is a consequence of immaterialism and constitutes a decisive element in the fight against scepticism. The very being of the thing is now decided on the basis of thought. Berkeley is often presented as a thinker who breaks with the philosophers before him. If this view is right, (...) it is also incomplete. We show that the identification of the idea with the real thing represents the culmination of speculations born during the Middle Ages, and repeated in cartesianism itself. (shrink)

As a brief lexical analysis shows us, Descartes elaborated two concepts of reality. His first concept of reality, mainly thematised in Meditation V, is rather traditionnal: real...

As a brief lexical analysis shows us, Descartes elaborated two concepts of reality. His first concept of reality, mainly thematised in Meditation V, is rather traditionnal: real...

La question des mondes possibles, quel que soit ce que le syntagme recouvre, est assurément une sorte de non-lieu cartésien. En conséquence, notre propos voudrait surtout contribuer, en faisant apparaître les motifs profonds qui amènent Descartes à refuser jusqu’aux termes d’une problématique qui lui est pourtant largement contemporaine, à élucider les conditions théoriques qui, à l’inverse, semblent requises pour que la notion retrouve sa consi...

Jean-Christophe Anderson Cet article interroge la présence, dans la Critique de la raison pure, d’une « clause anthropologique » redoublant le procès de la raison. À partir de la critique formulée par Husserl, selon laquelle Kant se montrerait coupable, en dépit de ses percées transcendantales, d’une forme de relativisme anthropologique, il s’agit plus précisément de clarifier la fonction limitative de l’incise « pour nous hommes » qui ponctue le texte de la première Critique. En dépit des apparences qui ont pu (...) mener Husserl à soutenir que Kant cherche à expliquer par cette clause la validité universelle des jugements synthétiques a priori, mais se trouve par le fait même à limiter cette validité, il est possible de soutenir que l’humanité de notre pouvoir de connaître n’est jamais présupposée par Kant et constitue en réalité une découverte de la raison à son propre sujet. (shrink)

Cette contribution examine les rapports entre le matérialisme des intérêts que revendique Bakounine dans ses derniers textes et la critique qu’il propose des notions d’intérêt général, de représentation politique et de centralisation dans La théologie politique de Mazzini et l’Internationale. Son objet est de montrer que la prise en compte du rôle social et historique des intérêts rend caduque toute possibilité d’un intérêt général qui viendrait à son tour fonder la légitimité d’une représentation politique dans une assemblée centraliste. La première (...) partie de l’article examine le rapport entre ce matérialisme des intérêts et la conception matérialiste de l’histoire proposée par Marx et Engels. La seconde insiste sur la critique de l’intérêt général comme fiction et sur l’impossibilité qui en découle de toute représentation dans le cadre d’un système centralisé, la reconnaissance de cette impossibilité débouchant même sur une critique du mandat impératif. (shrink)

La fameuse « Préface-annexe » de La Religieuse reprend le texte de la « confession » que, dix ans plus tôt, Grimm avait publié dans son périodique pour confesser son rôle dans la mystification qui avait été jouée au marquis de Croismare. La « reprise » de Diderot accompagne la résurrection du roman que Grimm avait enterré, sans se soucier des affirmations contradictoires qui en résultent. La polygraphie de Diderot est polyphonie ; elle participe de la représentation des pouvoirs de (...) l’écriture, que conquiert Suzanne, l’héroïne du roman. (shrink)

Poly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP‐1 (113 kDa), the founding member, and PARP‐2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding (...) novel PARPs now extends considerably the field of poly(ADP‐ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post‐translational modification of proteins. This review summarizes our present knowledge of this emerging superfamily, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders. A provisional nomenclature is proposed. BioEssays 26:882–893, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Cette contribution cherche à déterminer les rapports entre anarchie et démocratie chez Proudhon en partant de la place qu’il accorde au conflit. La première partie revient sur la prise en compte de ce que Proudhon nomme antagonisme ou antinomie et sur les différents types de conflits qu’il range sous cette rubrique, qui est au centre de son projet d’ontologie sociale. La deuxième partie s’intéresse à un cas d’antinomie, à la fois limite et fondamental : celui de la différence sexuelle, qui (...) est désignée comme une antinomie tout en se voyant dénier le statut de rapport conflictuel. La dernière partie montre comment la prise en compte du conflit chez Proudhon conduit à une critique de la démocratie et à un projet positif désigné par le terme de fédéralisme. (shrink)

Cette contribution cherche à déterminer les rapports entre anarchie et démocratie chez Proudhon en partant de la place qu’il accorde au conflit. La première partie revient sur la prise en compte de ce que Proudhon nomme antagonisme ou antinomie et sur les différents types de conflits qu’il range sous cette rubrique, qui est au centre de son projet d’ontologie sociale. La deuxième partie s’intéresse à un cas d’antinomie, à la fois limite et fondamental : celui de la différence sexuelle, qui (...) est désignée comme une antinomie tout en se voyant dénier le statut de rapport conflictuel. La dernière partie montre comment la prise en compte du conflit chez Proudhon conduit à une critique de la démocratie et à un projet positif désigné par le terme de fédéralisme. (shrink)